Come join us

Eleven Therapeutics is on a mission to develop the next generation of nucleic acid therapeutics by harnessing the power of combinatorial chemistry and A.I., transforming drug discovery and development into a programmable process. Our team consists of world class scientists and entrepreneurs, with a proven track-record in breakthrough innovations and therapeutic R&D.

Our discovery engine integrates deep expertise in bio-engineering, chemistry, genomics and computer science. Our resultant pipeline is rapidly expanding, focusing on a multitude of respiratory diseases, including antiviral prophylactics and treatments for non-infectious diseases of substantial unmet medical need. Eleven champions Diversity and Inclusion, and spans multiple geographies, operating across Cambridge (UK), Tel-Aviv (Israel), and Boston (US).

Join us as Sr Scientist, Nanoparticle Development at our Cambridge, UK site, to expand and mature our growing pipeline of metabolic and respiratory RNA-based therapeutics.

Apply here!

In this position you will be responsible for:

• Develop, optimize and assess nanoparticle formulations for nucleic acid therapeutics’ delivery applications, specifically using lipid nanoparticles, as well as other modalities
• Tailor LNP formulation solutions to diverse types of payloads, functionalized moieties, and nanoparticle properties as defined by the target organ
• Design and conduct analytical experiments to characterise nanoparticles
• Design and perform HPLC method development and validation
• Collaborate with cross-functional teams to advance drug delivery projects, tailored to a variety of routes  of administrations (e.g., intranasal, nebulization, IV and/or SC), target organs, PK and PD requirements
• Provide technical expertise and guidance to junior cross-functional team members
• Contribute to the writing of method, SOPs, scientific papers and patent applications
• Present routinely at team meetings and company-wide settings

• Effectively resolve scientific and technical challenges using knowledge and subject matter expertise/ experience to enable program progression

What you will bring to the table:

• PhD in Nanoparticle Science, Analytical Chemistry, Organic Chemistry, Pharmaceutical Science or a related field
• At least 2 years of experience in a pharmaceutical laboratory setting: a must
• Extensive experience in nanoparticle synthesis and characterization, particularly with lipid nanoparticles
• Experience in method development and validation, e.g., using HPLC
• Experience working in a Quality Assurance environment
• Experience in organic synthesis is a plus
• Experience in drug delivery research is a plus

• Stellar references

Personal capabilities:

• Proven ability to be flexible and work well independently in a fast-paced environment while managing multiple, competing priorities, and maintaining a strong focus on detail
• “Business partner” mindset, the desire to collaborate with our teams to innovate and drive business forward, while protecting the organization
• Hands-on, proactive approach, yet able to adapt and change priorities accordingly

• Strong analytical and problem-solving skills
• Excellent verbal and written communication skills, including remote reporting structures

What do we offer:

• Joining a multidisciplinary global cutting-edge team.
• A competitive compensation package.
• Space to innovate and impact in developing solutions to unmet needs.

Apply here!

Eleven Therapeutics is on a mission to develop the next generation of nucleic acid therapeutics by harnessing the power of combinatorial chemistry and A.I., transforming drug discovery and development into a programmable processor. Our team consists of world-class scientists and entrepreneurs with a proven track record in breakthrough innovations and therapeutic R&D.  

Our discovery engine integrates deep expertise in bio-engineering, chemistry, genomics and computer science. We orchestrate these technologies into highly-efficient processes for mapping the vast combinatorial space of potential oligonucleotide molecules to optimise our candidate therapeutics from the get-go. We then pursue a rigorous R&D process to ensure the pharmaceutical properties of our warheads, their delivery excipients and administration devices all fit the Target Product Profile in the most cost-effective manner. Our pipeline is rapidly expanding, focusing on a multitude of respiratory diseases, including antiviral prophylactics and non-infectious diseases of substantial unmet medical need. Our company champions Diversity and Inclusion and spans multiple geographies, operating across Cambridge (UK), Tel Aviv (Israel), and Boston (US). 

We seek an experienced In Vivo Scientist to join our growing team at our Cambridge site. The ideal candidate will have an MSc degree (PhD an advantage), 3-5 years of in vivo work experience in academic or industry settings, a proven track record of planning and executing in vivo studies, strong team working skills, and stellar references. Previous experience in respiratory or metabolic diseases is an advantage.

Apply here!

Key Responsibilities:

• Responsible for the execution of exploratory preclinical studies, including proof-of-principle efficacy and safety assessments, translational and biomarker studies, MoA and early PK/PD.
• Leverage a variety of in vivo techniques at in-house and CRO vivarium, including end-to-end conduct of in vivo experiments, from Test Article preparation and qualification, varied routes of administration, repeat dosing protocols, repeat sampling and monitoring protocols, extensive samples collection and storage protocols for biomarkers, toxicology, PK and spatial/transcriptomic profiling. 
• As a team member, contribute to planning the in vivo discovery and development programs.
• Collaborate closely with colleagues in peer functional departments, including Discovery, Technology Innovation, Data Sciences, and CMC.
• Manage and coordinate CRO services associated with the pre-and post-processing of materials and samples from in-life studies. 
• Collaborate with and support internal staff in the design, execution, and interpretation of in vitro, organoid, and ex vivo studies.
• Effectively resolve scientific and technical challenges using knowledge and subject matter expertise.
• Communicate project evolvements and directions promptly and effectively in internal and external meetings.
• Maintain knowledge of relevant literature and preclinical techniques.
• Comply with all home office regulations.

Qualifications:

• MSc (PhD an advantage) in relevant fields
• 3-5 years of hands-on in vivo work experience in academic or industry settings
• Proven track record of executing in vivo studies, including diverse routes of administration (IV, IP, IN, nebulisation, IT), monitoring techniques (IVIS, BAL/blood/urine collection), and sample collection (pre-euthanasia perfusion, cell dissociation, snap freeze, fixation, etc.)
• Strong teamwork skills
• Stellar references
• Previous experience in respiratory and/or metabolic diseases is an advantage.

We offer a competitive salary and opportunities for professional growth and development. If you are passionate about drug discovery and in vivo science and want to be part of an innovative and dynamic startup, we want to hear from you!

Apply here!

Are you an enthusiastic molecular biologist with a passion for developing new cutting-edge technologies in RNA therapeutics? Do you wish to join a vibrant, creative team that makes a difference in patients’ lives? If so – look no further!

Apply here!

Job Description

Eleven Tx is seeking to hire a passionate and innovative scientist to join our RNA Technology team and aid our efforts in developing a new generation of RNA-based therapies. The successful candidate will utilise state-of-the-art techniques aimed at tackling today’s challenges in the delivery, durability, and long-lasting effects of life-saving RNA therapies. We are looking for a creative and well-rounded molecular biologist, who demonstrates skills in nucleic acid R&D and has a passion for developing cutting edge RNA-based technologies.

Key Responsibilities

• You will take part in the development of combinatorial platforms for the discovery of new RNA delivery pathways and novel RNA modification strategies.
• You will identify and implement novel tools in molecular and cell biology, propose experimental strategies, and work at the bench to implement and troubleshoot experimental challenges.
• Eleven fosters an interdisciplinary environment, where you will work closely with other team members, and collaborate with the Artificial Intelligence and Chemistry teams to further develop new areas of research aimed to provide safe, effective, and durable therapeutics.

Required experience and skills 

• PhD in Molecular Biology, Cell Biology or related field
• 3+ years academic or industry experience in Molecular Biology and Nucleic Acid techniques 
• Hands-on experience in mammalian cell culture and cell-based assays
• Hands-on experience in cloning and in NextGen sequencing

Soft skills

• Strong teamwork skills
• Excellent verbal and written communication capabilities
• Strong analytical and problem-solving skills
• Hands-on, proactive approach, yet able to adapt and change priorities in a fast-paced environment 

What do we offer? 

• Becoming a part of an impact-driven venture 
• A place to grow and fulfil your aspirations
• Competitive compensation package

Apply here!

About Eleven Tx

Eleven Therapeutics is on a mission to develop the next generation of nucleic acid therapeutics by harnessing the power of state-of-the-art RNA biology, combinatorial chemistry and A.I., transforming drug discovery and development into a programmable process. Our team consists of world class scientists and entrepreneurs, with a proven track-record in breakthrough innovations and therapeutic R&D. Our discovery engine integrates deep expertise in bio-engineering, chemistry, genomics and computer science. Our resultant pipeline is rapidly expanding, focusing on a multitude of respiratory diseases, including antiviral prophylactics and treatments for non-infectious diseases of substantial unmet medical need. Eleven Tx champions diversity and inclusion, and spans multiple geographies, operating across Cambridge (UK), Tel-Aviv (Israel), and Boston (US). 

Are you an enthusiastic molecular biologist with a passion for developing new cutting-edge technologies in RNA therapeutics? Do you wish to join a vibrant, creative team that makes a difference in patients’ lives? If so – look no further!

Apply here!

Job Description

Eleven Tx is seeking to hire a passionate and innovative Senior Scientist to join our RNA Technology team and aid our efforts in developing a new generation of RNA-based therapies. The successful candidate will utilise state-of-the-art methods aimed at tackling today’s challenges in the delivery, durability, and long-lasting effects of life-saving RNA therapies. We are looking for a well-rounded molecular biologist with a proven track record of high impact publications, who demonstrates skills in nucleic acid R&D and has a passion for developing cutting edge RNA-based technologies.

Key Responsibilities

As a senior scientist you will contribute to the design and development of combinatorial platforms for the discovery of new RNA delivery pathways and novel RNA modification strategies. You will identify and implement novel tools in RNA and cell biology, propose experimental designs and strategies, and work at the bench to implement and troubleshoot experimental challenges. Eleven fosters an interdisciplinary environment, where you will work closely with the Artificial Intelligence and Chemistry teams to further develop new areas of research aimed to provide safe, effective, and durable therapeutics.

Required experience and skills 

• PhD in Molecular Biology, Cell Biology or related field
• 5+ years academic or industry experience in Molecular Biology and in Mammalian Cell Biology
• Proven track record of executing cutting-edge DNA/ RNA techniques, including NGS.
• Preferable: Expertise in developing new high throughput technologies. 

Soft skills 

• Strong teamwork skills
• Excellent verbal and written communication capabilities
• Strong analytical and problem-solving skills
• Hands-on, proactive approach, yet able to adapt and change priorities in a fast-paced environment 
• Proven ability to work independently while managing multiple, competing priorities

What do we offer? 

• Becoming a part of an impact-driven venture 
• A place to grow and fulfil your aspirations
• Competitive compensation package

Apply here!

About Eleven Tx

Eleven Therapeutics is on a mission to develop the next generation of nucleic acid therapeutics by harnessing the power of state-of-the-art RNA biology, combinatorial chemistry and A.I., transforming drug discovery and development into a programmable process. Our team consists of world class scientists and entrepreneurs, with a proven track-record in breakthrough innovations and therapeutic R&D. Our discovery engine integrates deep expertise in bio-engineering, chemistry, genomics and computer science. Our resultant pipeline is rapidly expanding, focusing on a multitude of respiratory diseases, including antiviral prophylactics and treatments for non-infectious diseases of substantial unmet medical need. Eleven Tx champions diversity and inclusion, and spans multiple geographies, operating across Cambridge (UK), Tel-Aviv (Israel), and Boston (US). 

Apply here!

Job Description

Eleven Tx is seeking a highly skilled and passionate oligonucleotide (ON) chemist to join our team in developing the next generation of RNA therapeutics. The successful candidate will use state-of-the-art techniques to enhance RNA stability and improve cell delivery, as well as aid in the development of unique therapeutic platforms to discover new RNA molecules. Working alongside other chemists, molecular biologists, and AI experts, this person will systematically explore new and current chemical modifications to improve drug efficacy. He/she will be highly skilled in synthesising, analysing, and handling modified oligonucleotides and have an ability to adapt in a fast-paced research environment. He/she will also be responsible for developing high-throughput assays to discover new ultra-potent RNAs and contribute to the construction of our therapeutic pipeline and chemistry facilities. The ideal candidate will be a well-rounded oligonucleotide chemist keen to work in a multidisciplinary research environment.

Key Responsibilities

• Lead the development and chemical synthesis of modified oligonucleotides using automated solid phase synthesis (SPS)
• Utilise variety of purification and analytical techniques to evaluate the purity and structural integrity of newly synthesised ONs
• Collaborate closely with molecular biologists and AI experts to design biochemical assays and understand the structure-activity relationship and therapeutic implications of RNA modalities
• Utilise expertise to generate libraries of therapeutic RNA and generate the data for AI algorithms

Key Capabilities

• Excellent knowledge of solid phase ON synthesis, phosphoramidite chemistry, and hands-on experience of automated ON synthesizers
• Advanced and up to date knowledge of ON protecting groups and different deprotection strategies in SPS
• Expertise in characterisation and purification of ONs and their conjugates by LCMS and HPLC
• Strong analytical aptitude with an ability to work in the interface of chemistry and biology
• Excellent communication and interpersonal skills
• Ability to voice opinions and share ideas with the rest of the team
• High professional integrity and commitment to excellence in execution
• Passion for realizing the potential of fundamental scientific discoveries and commercialization

Qualifications

• PhD or equivalent in ON/peptide/synthetic organic chemistry (postdoctoral or industrial experience in the SPS is preferred)
• Strong understanding of nucleic acid modalities, modifications, and conjugation chemistry
• Strong track record of scientific contributions including peer reviewed publications or patent applications

Apply here!